The current issue of Neura features an overview of neuromyelitis optica (NMO), including its pathophysiology and treatment and current views on differentiating NMO from multiple sclerosis (MS). Other articles include an analysis of the association between traumatic brain injury and neurodegenerative disease, an overview of fluctuations in quality of life in Parkinson’s disease (PD), and a Highlights section that summarizes several articles published recently in the literature.