Featured in this issue of MS Scan is a summary of recently published results from trials of MS therapeutics, specifically, those that are taken orally. The latest clinical trial results of the oral MS therapies cladribine and fingolimod are discussed, along with a round-up of research data on several other oral therapies under investigation. A review of the mind-body connection in MS addresses the roles of depression, gender, and cognitive impairment in the MS disease course.