The current issue of Neura features an overview of the links between depression and neurodegenerative disease, including information on theories of depression, diagnosis and treatment, and depression and neurodegenerative disease as comorbid conditions. Other articles include an analysis of strategies of combination therapy as treatment for multiple sclerosis (MS), the second part of our 2-part feature on delayed-start trials (DSTs), and a Highlights section that summarizes several articles published recently in the literature.